| [1] | 
				
					杨学敏,杨开宁,张凤玲.药物动力学临床实用指南[M].北京:军事医学科学出版社,2004,391-405.
					 | 
			
		
				| [2] | 
				
					张继稳,裴小兵.残数法计算单室模型药物血管外多剂量给药的吸收和清除动力学参数[J].安徽医科大学学报,2004,39(1):34-36.
					 | 
			
		
				| [3] | 
				
					Jang J S R, Sun C T, Mizutai E.Neuro-Fuzzy and Soft Computing: A Computational Approach to Learning and Machine Intelligence[M].US Ed: Prentice Hall,1997,112-137.
					 | 
			
		
				| [4] | 
				
					Nelder A, Mead R.A simplex method for function optimization[J].Computation J,1965,7(12):308-313.
					 | 
			
		
				| [5] | 
				
					Jeffery C L, James A R, Margaret H W,et al.Convergence properties of the Nelder-Mead simplex method in low dimensions[J].Society for Industrial and Applied Mathematics,1998,9(1):112-147.
					 | 
			
		
				| [6] | 
				
					刘利斌,张文,谢竹诚.基于改进单纯形算法的药物动力学参数计算[J].浙江科技学院学报,2007,19(1):4-6.
					 | 
			
		
				| [7] | 
				
					de Castro L N, Timmis J.Artificial immune systems as a novel soft computing paradigm[J].Soft Computing,2003,7(8):526-544. doi:  10.1007/s00500-002-0237-z
					 | 
			
		
				| [8] | 
				
					Chun J S, Hahn S Y. A study on comparison of optimization performances between immune algorithm and other heuristic algorithms[J].IEEE Transactions on Magnetics,1998,34(5):2972-2975. doi:  10.1109/20.717694
					 | 
			
		
				| [9] | 
				
					谢开贵,曾晓晖,李春燕,等.免疫算法与其他随机优化算法的比较分析[J].重庆大学学报,2003,26(11):43-47.
					 | 
			
		
				| [10] | 
				
					Yuan S F, Chu F L.Fault diagnosis based on support vector machines with parameter optimization by artificial immunization algorithm[J].Mechanical System and Signal Processing,2007,21(3):1318-1330. doi:  10.1016/j.ymssp.2006.06.006
					 | 
			
		
				| [11] | 
				
					马秀丽,刘芳,焦李成.基于免疫克隆算法的协同神经网络参数优化[J]. 红外与毫米波学报,2007,26(1):38-42.
					 | 
			
		
				| [12] | 
				
					何宏,钱锋.基于免疫进化算法的PID参数整定[J].计算机应用,2002,27(5):1175-1176,1196.
					 | 
			
		
				| [13] | 
				
					de Castro L N,Timmis J.An artificial immune network for multimodal function optimization[A].In:Proceedings of IEEE Congress on Evolutionary Computation (CEC'02)[C].1.Honolulu:IEEE Service Center,2004,674-699.
					 | 
			
		
				| [14] | 
				
					de Franca F O, von Zuben F J, de Castro L N. An artificial immune network for multimodal function optimization on dynamic environments[A].In:Proc of the GECCO Conf[C].Washington DC:ACM Press,2005,289-296.
					 | 
			
		
				| [15] | 
				
					王广基.药物代谢动力学[M].北京:化学工业出版社,2005,88-120.
					 | 
			
		
				| [16] | 
				
					黄晓晖,谢海棠,孙瑞元.拉普拉斯变换及其在药代动力学中的应用[J].中国临床药理学与治疗学,2001,6(1):59-63.
					 | 
			
		
				| [17] | 
				
					Ada G L, Nossal G J V.The clonal selection theory[J].Scientific American,1987,257(2):50-57.
					 | 
			
		
				| [18] | 
				
					Jerne N K. Towards a network theory of the immune system[J].Annals of Immunology,Ser C,1974,125(1/2):373-389.
					 | 
			
		
				| [19] | 
				
					黄晓晖,史军,李俊,等.药代动力学和药效动力学中数学建模与模拟的基本原理(2)[J].中国临床药理学与治疗学, 2007,12(3):334-341.
					 | 
			
		
				| [20] | 
				
					de Castro L N,von Zuben F J. Learning and optimization using the clonal selection principle[J].IEEE Trans on Evol Comp,2002,6(3):239-251. doi:  10.1109/TEVC.2002.1011539
					 | 
			
		
				| [21] | 
				
					Renders J, Bersini H. Hybridizing genetic algorithms with hill-climbing methods for global optimization: two possible ways[A].In:Proceedings of the First IEEE Conference on Evolutionary Computation[C].Orlando:IEEE Press,1994,312-317.
					 | 
			
		
				| [22] | 
				
					Yen J, Liao J,Randolph D,et al.A Hybrid approach to modeling metabolic systems using a genetic algorithms and the simplex method[J].IEEE Transactions on Systems,Man,and Cybernetics,Part B,1998,28(2):173-191.
					 | 
			
		
				| [23] | 
				
					余建军,孙树栋,王军强.单纯形免疫算法及其在高维非凸函数优化中的应用[J]. 机械科学与技术, 2007,26(3):296-303.
					 | 
			
		
				| [24] | 
				
					de Castro L N, von Zuben F J. aiNet: An artificial immune network for data analysis[A].In:Abbass H A,Saker R A, Newton C S,Eds.Data Mining: A Heuristic Approach[C].USA: Idea Group Publishing, 2001, 231-259.
					 | 
			
		
				| [25] | 
				
					Westmoreland C L,Hoke J F,Sebel P S,et al.Pharmacokinetics of remifentanil (GI87084B) and its major metabolite (GR90291) in patients undergoing elective surgery[J].Anesthesiology,1993,79(5):893-903. doi:  10.1097/00000542-199311000-00005
					 | 
			
		
				| [26] | 
				
					Pitsiu M, Wilmer A,Bodenham A,et al.Pharmacokinetics of remifentanil and its major metabolite, remifentanil acid, in ICU patients with renal impairment[J].British Journal of Naesthesia,2004,92(4):493-503. doi:  10.1093/bja/aeh086
					 |