T型分叉血管的定常/脉动流动和大分子传质

李丁; 温功碧

T型分叉血管的定常/脉动流动和大分子传质

李丁,
温功碧

北京大学, 力学与工程科学系, 湍流与复杂系统研究国家重点实验室, 北京, 100871

基金项目: 国家自然科学重点基金资助项目(10002003)

详细信息

作者简介:
李丁(1973- ),辽宁鞍山人,硕士;温功碧(1935- ),女,四川人,教授(E-mail:wengb@mech.pku.edu.cn).

中图分类号: R318.01
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- 文章访问数: 2496
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- 被引次数: 0
出版历程
- 收稿日期: 2001-12-28
- 修回日期: 2002-12-08
- 刊出日期: 2003-05-15

The Steady/Pulsatile Flow and Macromolecular Transport in T-Bifurcation Blood Vessels

Department of Mechanics and Engineering Science, niversity, Beijing 100871, P.R.China

摘要

摘要: 采用计算流体动力学方法,数值求解了T型分叉流动的定常/脉动流场和低密度脂蛋白(LDL)以及血清白蛋白(Albumin)的浓度分布。计算了雷诺数、主管和支管的流量比等参数对流场和大分子传质的影响,计算结果表明,流体动力学因素影响大分子的分布和跨壁渗透,在动脉硬化的发生和发展过程中起着重要的作用。在流动发生分离处,即支管入口外侧壁面剪应力变化最剧烈,这儿LDL和Albumin的壁面浓度变化也是最剧烈,是动脉硬化危险区。
- T型分叉 /
- 血管定常流 /
- 血管非定常流 /
- 大分子传质
Abstract: A numerical analysis of the steady and pulsatile,macromolecular(such as low density lipopotein(LDL),Albumin)transport in T-bifurcation was proposed.The influence of Reynolds number and mass flow ratio etc parameters on the velocity field and mass transport were calculated.The computational results predict that the blood flow factors affect the macromolecular distribution and the transport across the wall,it shows that hemodynamic paly an important role in the process of atherosclerosis.The LDL and Albumin concentration on the wall varies most greatly in flow bifurcation area where the wall shear stress varies greatly at the branching vessel and the atherosclerosis of ten appears there.
- T-bifurcation /
- steady blood flow /
- pulsatile blood flow /
- macromolecular transport

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参考文献(22)

[1]	Back L H, Liem T K, Kwack E Y. et al. Flow measurements in a highly curved atherosclerotic coronary artery cast on man[J]. J Biomechanical Engineering,1992,114(2):232-240.
[2]	Perktold K, Resch M. Numerical flow studies in human carotid artery bifurcations: basic discussion of the geometric factor in atherogenesis[J]. J Biomedical Eng,1990,12(1):111-123.
[3]	Fry D L. Certain histological and chemical responses of the vascular interface of acutely induced mechanical stress in the aorta of the dog[J]. Circulation Research,1969,24(1):93-109.
[4]	Fry D L, Vaishnav R N. Mass transport in the arterial wall basic hemodynamics and its role[A].In:Patel D J, Vaishnav R N Eds. Disease Processes[C],University Park Press,1980,77-95.
[5]	Liepsch D, Moravec S, Rastogi A K, et al. Measurement and calaulations of laminar flow in a ninety degree bifurcation[J]. J Biomechanics,1982,15(7):473-485.
[6]	Resch M,Perktold K,Reinfried O P. Three-dimensional numerical analysis of pulsatile flow and wall shear stress in the carotid artery bifurcation[J]. J Biomechanics,1991,24(6):409-420.
[7]	Kawaguti M, Hamano A. Numerical study of bifurcating flow of a viscous fluid[J]. J Phys Soc (Japan),1979,46(4):1360-1365.
[8]	Kawaguti M, Hamano A. Numerical study of bifurcating flow of a viscous fluid-Ⅱ:Pulsatile flow[J]. J Phys Soc (Japan),1980,49(2):817-824.
[9]	O'Brien V, Ehrlich L W. Simulation of unsteady flow at renal branches[J]. J Biomechanics,1977,10(10):623-631.
[10]	Lutz R J, Hsu L, Menawat A. Comparision of steady and pulsatile flow in a double branching arterial model[J]. J Biomechanics,1983,16(9):753-766.
[11]	Fernandez R C, DeWitt K J, Botwin M R. Pulsatile flow through a bifurcation with applications to arterial disease[J]. J Biomechanics,1976,9(9):575-580.
[12]	Khodadadi J M, Vlachos N S, Liepsch D. LDL measurements and numerical prediction of pulsatile laminar flow in a plane 90-degree bifurcation[J]. J Biomechanical Engineering,1988,110(2):129-136.
[13]	Rappitisch G, Perktold K. Pulsatile albumin transport in large arteries: A numerical simulation study [J]. J Biomechanicl Engeering,1996,118(4):511-519.
[14]	Barter P J, Rye K. A high density lipoproteins and coronary heart disease[J]. Atherosclerosis,1996,121(1):1-12.
[15]	Ojha M. Spatial and temporal variations of wall shear stress within an end-to-side arterial anastomosis model[J]. J Biomechanics,1983,26(12):1377-1388.
[16]	He X Y, Ku D N. Pulsatile flow in the human left coronary artery bifurcation: average conditions[J]. J Biomechanical Engineering,1996,118(1):74-82.
[17]	Back L H, Liem T K, Kwack E Y, et al. Flow measurements in a highly curved atherosclerotic coronary artery cast of man[J]. J Biomechanical Engineering,1992,114(2):232-240.
[18]	Karino T, Deng X Y, Naiki T. Flow-dependent concentration polarization of lipoproteins at the blood-endothelium boundary[A].In:Hochmuth R M,Langrana N A,Hefzy M S Eds.Proceedings of the 1995 Bioengineering Conference[C].Berlin,Heidelberg,New York:Springer-Verlag,1995.
[19]	Jo H, Dull R O, Hollis T M, et al. Endothelial albumin permeability is shear dependent, time dependent and reversible[J]. American J Physiology,1991,260:H1992-H1996.
[20]	Friedman M H,Peters O J,Bargeron C B,et al. Shear-dependent thickening of the human arterial intima[J]. Atherosclerosis,1986,60(2):161-170.
[21]	Rappitsch G, Pektold K. Computer simulation of convective diffusion processes in large arteries[J]. J Biomechanics,1996,29(2):207-215.
[22]	Langeler E G, Ineke S H, Victor W M,et al.Passage of low density lipoproteins through monolayers of human arterial endothelidal cells-effects of vasoactive substance in an in vitro[J]. Arteriosclerosis,1989,9(4):550-559.