恶性肿瘤的传质问题(Ⅱ)——药物传输部分

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Mass Transport in Solid Tumors(Ⅱ)——Drug Delivery

Department of Mechanics and Engineering Science, Peking University, Beijing 100871, P. R. China

摘要: 本文提出肿瘤中药物传输的三重介质模型.基于第(Ⅰ)部分流体动力学的计算结果,采用有限元方法,在不同初始和边界条件下求解了对流-扩散方程组.根据计算结果,详细分析了药物注射方式、分子量、淋巴、药物结合和坏死区等对抗体免疫球蛋白IgG及其片断Fab在肿瘤中浓度分布的影响.
- 肿瘤 /
- 药物传输 /
- 三重介质模型 /
- 对流—扩散方程 /
- 浓度分布
Abstract: Based on the flow field solution of the three-porous-medium model for tumor microcirculation,the diffusion-convection equations are solved with varions initial and boundary conditions using finite element method.The concentration profile of two therapeutic agents immunoglobulin G(lgG) and its antigen-binding fragment(Fab) in blood,lymph and intersitial flaid are obtained for normal-tissue-surrounded tumor.The effect of tumor microvasculature,lymph function,drug injection mode,the molecular weight and binding kinetics of the drug on the distribution in tumors are considered.
- three-porous-medium model /
- solid tumor /
- drug delivery /
- diffusion-convection equations /

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