留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

消除毛细管电泳槽道中弯道导致的扩散效应的新方法

李志华 林建忠 聂德明

李志华, 林建忠, 聂德明. 消除毛细管电泳槽道中弯道导致的扩散效应的新方法[J]. 应用数学和力学, 2005, 26(6): 631-636.
引用本文: 李志华, 林建忠, 聂德明. 消除毛细管电泳槽道中弯道导致的扩散效应的新方法[J]. 应用数学和力学, 2005, 26(6): 631-636.
LI Zhi-hua, LIN Jian-zhong, NIE De-ming. New Approach to Minimize Dispersion Induced by Turn in the Capillary Electrophoresis Channel Flows[J]. Applied Mathematics and Mechanics, 2005, 26(6): 631-636.
Citation: LI Zhi-hua, LIN Jian-zhong, NIE De-ming. New Approach to Minimize Dispersion Induced by Turn in the Capillary Electrophoresis Channel Flows[J]. Applied Mathematics and Mechanics, 2005, 26(6): 631-636.

消除毛细管电泳槽道中弯道导致的扩散效应的新方法

基金项目: 国家自然科学基金(重大)资助项目(20299030)
详细信息
    作者简介:

    李志华(1965- ),男,浙江人,副教授,博士(E-mail:lizhihua@mail.hz.zj.cn);林建忠(联系人.Tel:+86-571-87952882;Fax:+86-571-87951464;E-mail:jzlin@sfp.zju.edu.cn).

  • 中图分类号: O363.2;O357

New Approach to Minimize Dispersion Induced by Turn in the Capillary Electrophoresis Channel Flows

  • 摘要: 首先分析了毛细管通道中流动的弯道效应及其产生的原因,接着在建立电渗流场数学模型的基础上,用有限差分法对弯道处内外壁面上不同电荷分布时的扩散进行了数值模拟.根据计算结果,提出了一种基于改变弯道处内外壁面上电荷分布的新方法,以此使流场的弯道效应最弱.同时还建立了分析和确定弯道处最佳电荷分布的优化方法.结果表明,该方法能极大地消除毛细管通道中的流动弯道效应.
  • [1] Culbertson C T, Jacobson S C, Ramsey J M. Dispersion sources for compact geometries on microchips[J].Analytical Chemistry,1998,70(18):3781—3789. doi: 10.1021/ac9804487
    [2] Paegel B M, Lester D H,Simpson P C,et al.Turn geometry for minimizing band broadening in microfabricated capillary electrophoresis channels[J].Analytical Chemistry,2000,72(14):3030—3037. doi: 10.1021/ac000054r
    [3] Molho J I, Herr A E, Mosier B P,et al.Optimization of turn geometries for microchip electrophoresis[J].Analytical Chemistry,2001,73(7):1350—1360. doi: 10.1021/ac001127+
    [4] Qiao R, Aluru N R. Dispersion control in nano-channel systems by localized zeta-potential variations[J].Sensors and Actuators A: Physical,2003,104(3):268—274. doi: 10.1016/S0924-4247(03)00029-3
    [5] Schwer C, Kenndler E. Electrophoresis in fused-silica capillaries—the influence of organic-solvents on the electroosmotic velocity and the zeta-potential[J].Analytical Chemistry,1991,63(17):1801—1807. doi: 10.1021/ac00017a026
    [6] Moseley M A, Deterding L J, Tomer K B,et al. Determination of bioactive peptides using capillary zone electrophoresis mass-spectrometry[J].Analytical Chemistry,1991,63(2):114—120. doi: 10.1021/ac00002a006
    [7] Johnson T J, Ross D, Gaitan M,et al. Laser modification of performed polymer microchannels: application to reduced band broadening around turns subject to electrokinetic flow[J].Analytical Chemistry,2001,73(15):3656—3661. doi: 10.1021/ac010269g
    [8] Hayes M A. Extension of external voltage control of electroosmosis to high-pH buffers[J].Analytical Chemistry,1990,71(17):3793—3798.
  • 加载中
计量
  • 文章访问数:  2400
  • HTML全文浏览量:  60
  • PDF下载量:  539
  • 被引次数: 0
出版历程
  • 收稿日期:  2003-06-16
  • 修回日期:  2005-01-25
  • 刊出日期:  2005-06-15

目录

    /

    返回文章
    返回