细胞趋硬性迁移的研究进展

杨月华; 姜洪源

doi:10.21656/1000-0887.420265

细胞趋硬性迁移的研究进展

doi: 10.21656/1000-0887.420265

杨月华,
姜洪源^,

中国科学技术大学工程科学学院近代力学系中国科学院材料力学行为和设计重点实验室，合肥 230026

基金项目:

国家自然科学基金（12002338；12025207；11872357）

中央高校基本科研业务费(WK2090000017)

安徽省自然科学基金（2008085QA24）

统筹推进世界一流大学和一流学科建设专项资金(YD2480002001)

详细信息

作者简介:
杨月华（1992—），男，特任副研究员(E-mail: hz293033@ustc.edu.cn);姜洪源（1979—），男，教授，博士生导师(通讯作者. E-mail: jianghy@ustc.edu.cn).

通讯作者:
姜洪源（1979—），男，教授，博士生导师(通讯作者. E-mail: jianghy@ustc.edu.cn).

中图分类号: O3
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- 文章访问数: 841
- HTML全文浏览量: 129
- PDF下载量: 137
- 被引次数: 0
出版历程
- 收稿日期: 2021-09-03
- 修回日期: 2021-09-10
- 刊出日期: 2021-10-01

Research Advances in Cell Durotaxis

YANG Yuehua,
JIANG Hongyuan^,

CAS Key Laboratory of Mechanical Behavior and Design of Materials，Department of Modern Mechanics, School of Engineering Science, University of Science and Technology of China, Hefei 230026, P.R.China

Funds:

The National Natural Science Foundation of China(12002338

12025207

11872357)

摘要

摘要: 细胞力学微环境可以调控许多细胞生理功能.特别地，在细胞力学微环境各种信号梯度的作用下，细胞可以定向地迁移.这些定向迁移可以显著影响伤口愈合、癌细胞转移和组织形貌发育等生理过程.目前为止，细胞的定向迁移主要包括：在化学药物梯度作用下的趋药性迁移，在黏附分子梯度作用下的趋触性迁移，以及在细胞外基质硬度梯度作用下的趋硬性迁移等.虽然细胞趋药性和趋触性迁移的力学机理得到了很好的研究，但是关于细胞趋硬性迁移的机制和作用还不清楚.该文重点介绍了细胞趋硬性的相关实验和理论研究进展，分析了不同研究间的联系与区别，讨论了细胞趋硬性迁移的潜在力学机制，提出尚存在的问题和未来可能的研究方向.
- 细胞力学微环境 /
- 细胞定向迁移 /
- 趋硬性迁移 /
- 体积变化 /
- 细胞极性
Abstract: The cellular mechanical microenvironment can regulate many cellular physiological functions. In particular, cells can migrate directionally under external cue gradients from their mechanical microenvironment. These directed migrations play critical roles in wound healing, cancer cell metastasis, and tissue morphology development. So far, directional cell migration mostly includes: the directional migration under chemical gradients (chemotaxis), the directional migration under adhesion gradients (haptotaxis), and the directional migration under mechanical gradients (durotaxis). Although the basic mechanisms of chemotaxis and haptotaxis are well characterized, the mechanism of durotaxis remains unclear. In this review, we describe the experimental and theoretical advances in the study of cell durotaxis, analyze the connections and differences among different studies, discuss the potential mechanical mechanism of cell durotaxis, and put forward the remaining problems and possible future research directions.
- cellular mechanical microenvironment /
- directional cell migration /
- cell durotaxis /
- volume regulation /
- cell polarity

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留言板

细胞趋硬性迁移的研究进展

doi: 10.21656/1000-0887.420265

作者简介:
杨月华（1992—），男，特任副研究员(E-mail: hz293033@ustc.edu.cn);姜洪源（1979—），男，教授，博士生导师(通讯作者. E-mail: jianghy@ustc.edu.cn).

通讯作者:
姜洪源（1979—），男，教授，博士生导师(通讯作者. E-mail: jianghy@ustc.edu.cn).

计量

Research Advances in Cell Durotaxis

计量

目录

留言板

细胞趋硬性迁移的研究进展

doi: 10.21656/1000-0887.420265

作者简介: 杨月华（1992—），男，特任副研究员(E-mail: hz293033@ustc.edu.cn);姜洪源（1979—），男，教授，博士生导师(通讯作者. E-mail: jianghy@ustc.edu.cn).

通讯作者: 姜洪源（1979—），男，教授，博士生导师(通讯作者. E-mail: jianghy@ustc.edu.cn).

计量

出版历程

Research Advances in Cell Durotaxis

计量

出版历程

目录

作者简介:
杨月华（1992—），男，特任副研究员(E-mail: hz293033@ustc.edu.cn);姜洪源（1979—），男，教授，博士生导师(通讯作者. E-mail: jianghy@ustc.edu.cn).

通讯作者:
姜洪源（1979—），男，教授，博士生导师(通讯作者. E-mail: jianghy@ustc.edu.cn).