软骨终板退化对颈椎椎间盘物质运输和力学响应的影响

刘景龙; 徐鹏; 李侨; 王丽珍; 樊瑜波

doi:10.21656/1000-0887.450017

软骨终板退化对颈椎椎间盘物质运输和力学响应的影响

doi: 10.21656/1000-0887.450017

刘景龙^{1, 2,},
徐鹏^{1, 2},
李侨^3, ,,
王丽珍^{1, 2, 4},
樊瑜波^{1, 3, 4}

1.
北京航空航天大学生物力学与力生物学教育部重点实验室，北京市生物医学工程高精尖创新中心，生物与医学工程学院，北京 100191
2.
杭州市北京航空航天大学国际创新研究院(北京航空航天大学国际创新研究院), 杭州 311115
3.
北京航空航天大学医学科学与工程学院，北京 100191
4.
北京航空航天大学虚拟现实技术与系统全国重点实验室，北京 100191

基金项目:

国家自然科学基金(“叶企孙”科学基金项目) U2241273

详细信息

作者简介:
刘景龙(1996—)，男，博士生(E-mail: jinglongliu@buaa.edu.cn)

通讯作者:
李侨(1993—)，女，博士(通讯作者. E-mail: qiaoli@buaa.edu.cn)

中图分类号: O39;R318.01
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- 文章访问数: 148
- HTML全文浏览量: 44
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- 被引次数: 0
出版历程
- 收稿日期: 2024-01-25
- 修回日期: 2024-05-09
- 刊出日期: 2024-06-01

Effects of Cartilage Endplate Degeneration on Metabolic Transport and Biomechanical Responses of Cervical Intervertebral Discs

LIU Jinglong^{1, 2
,},
XU Peng^{1, 2},
LI Qiao^{3
, ,},
WANG Lizhen^{1, 2, 4},
FAN Yubo^{1, 3, 4}

1.
Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, P.R.China
2.
Hangzhou International Innovation Institute, Beihang University, Hangzhou 311115, P.R.China
3.
School of Engineering Medicine, Beihang University, Beijing 100191, P.R.China
4.
State Key Laboratory of Virtual Reality Technology and Systems, Beihang University, Beijing 100191, P.R.China

摘要

摘要:
软骨终板内的液体流动是椎间盘营养供给和代谢废物运输的主要途径. 退化的终板刚度增加、渗透性和含水量下降，会影响椎间盘内物质运输和力学响应. 基于人体颈椎计算机断层扫描数据建立了C5-C6节段的多孔介质有限元模型. 对验证后的模型施加压缩、前屈、后伸、轴向旋转和侧弯五种载荷，通过改变终板渗透性、孔隙比和模量，分析了正常、钙化和硬化三种状态下椎间盘的响应. 结果表明：软骨终板退化增加了软骨终板和髓核的多孔压力，降低了软骨终板的流体速度. 前屈载荷下，与正常终板对比，钙化和硬化终板导致髓核内流体的多孔压力分别增加了50.8%和88.9%. 退化终板渗透率和含水量的降低导致髓核内液体不易流动，增加了髓核基体的应力，在压缩和轴向旋转载荷下，硬化终板导致髓核基体的最大主应力分别增加了122.2%和100.0%.
- 软骨终板退化 /
- 多孔介质建模 /
- 流体多孔压力 /
- 数值计算
Abstract:
The fluid flow in the cartilage endplate (CEP) is the main path of nutrient supply and metabolic waste transport within the intervertebral disc (IVD). The increased stiffness, the decreased permeability and the water content of the degenerated cartilage endplate influence the mechanical responses and material transport within the IVD. A porous finite element model for C5-C6 of the cervical spine was established based on the computed tomography (CT) images of an adult. After validation, loads of compression, flexion, extension, axial rotation and lateral bending were applied to this model to calculate the instantaneous responses of the IVD. The calcification and sclerosis in the CEP were simulated with increase of its modulus and decrease of its permeability and porosity, compared with a healthy case. The results show that, the pore pressures within the CEP and the nucleus pulposus (NP) increase and the fluid velocity decrease in the degenerated CEP. Under flexion, the pore pressure in the NP increase by 50.8% and 88.9% in calcified and sclerotic CEPs compared to the healthy endplate, respectively. The decreases of the permeability and the water content in the degenerated CEP hinder the fluid flow and increase the maximum principal stresses of the NP matrix by 122.2% and 100.0% under compression and axial rotation, respectively.
- cartilage endplate degeneration /
- porous media modeling /
- fluid porous pressure /
- numerical simulation

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图 1 C5-C6节段有限元模型的建立过程及各部分示意图

注为了解释图中的颜色，读者可以参考本文的电子网页版本，后同.

Figure 1. The construction process and components of the C5-C6 finite element model

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图 2 轴向压缩500 N时椎间盘高度丢失百分比验证^[30-31]

Figure 2. Validation of percentages of height losses of the FE model under a 500 N compression^[30-31]

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图 3 髓核及软骨终板在压缩、前屈、后伸、轴向旋转及侧弯载荷下的最大多孔压力

Figure 3. Maximum pore pressures in the nucleus pulposus and the cartilage endplate under compression(comp), flexion (flex), extension (ext), axial rotation (AR) and lateral bending (LB)

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图 4 髓核及软骨终板在压缩、前屈、后伸、轴向旋转及侧弯载荷下的最大流体速度

Figure 4. Maximum fluid velocities in the nucleus pulposus and the cartilage endplate under compression (comp), flexion (flex), extension (ext), axial rotation (AR) and lateral bending (LB)

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图 5 髓核在压缩、前屈、后伸、轴向旋转及侧弯载荷下的流体速度云图

Figure 5. Contours of fluid velocities in the nucleus pulposus under compression (comp), flexion (flex), extension (ext), axial rotation (AR) and lateral bending (LB)

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图 6 髓核及软骨终板在压缩、前屈、后伸、轴向旋转及侧弯载荷下的最大主应力

Figure 6. Maximum principal stresses in the nucleus pulposus and the cartilage endplate under compression (comp), flexion (flex), extension (ext), axial rotation (AR) and lateral bending (LB)

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图 7 髓核在压缩、前屈、后伸、轴向旋转及侧弯载荷下的最大主应力云图

Figure 7. Contours of maximum principal stresses in the nucleus pulposus under compression (comp), flexion (flex), extension (ext), axial rotation (AR) and lateral bending (LB)

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表 1 多孔介质有限元模型材料参数

Table 1. Material parameters of the porous finite element model

component		Young’s modulus E/MPa	Poisson’s ratio ν	void ratio e₀	permeability k₀/(mm⁴/(N·s))	reference
cortical bone		16 800	0.3	-	-	[23]
cancellous bone		450	0.3	0.41	5.773 5E-2	[16, 24]
posterior bone		3 500	0.3	-	-	[24]
articular cartilage		10	0.4	-	-	[19]
nucleus pulposus		1	0.49	5.67	1.56E-4	[16, 24]
annulus substance		Mooney-Rivlin C₁₀=0.133, C₀₁=0.033 3, D₁=0.6		2.45	1.56E-4	[16, 25]
annulus fibrosus		110	0.3	-	-	[25]
boney endplate		5 600	0.3	0.8	7.500E-2	[13, 19]
cartilage endplate	healthy calcified sclerotic	5 3 500	0.4	4 0.11	4.041E-3 4.041E-4 4.041E-5	[16, 24] [13, 26]
ligament	ALL	28.2	0.4	-	-	[27-28]
	PLL	23	0.4
	LF	3.5	0.4
	CL	4.8	0.4
	ISL	5	0.4

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表 2 髓核及软骨终板在压缩、前屈、后伸、轴向旋转及侧弯载荷下的最大多孔压力比较

Table 2. Comparison of maximum pore pressures in the nucleus pulposus and the cartilage endplate under compression (comp), flexion (flex), extension (ext), axial rotation (AR) and lateral bending (LB)

component	degree of cartilage endplate degeneration	loading condition
component	degree of cartilage endplate degeneration	comp	flex	ext	AR	LB
nucleus pulposus	calcified	12.5%	50.8%	1.4%	14.3%	1.5%
nucleus pulposus	sclerotic	55.0%	88.9%	1.4%	48.2%	19.7%
cartilage endplate	calcified	95.7%	97.9%	60.0%	42.2%	38.6%
cartilage endplate	sclerotic	169.6%	147.9%	80.0%	84.4%	56.1%

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表 3 髓核及软骨终板在压缩、前屈、后伸、轴向旋转及侧弯载荷下的最大流体速度比较

Table 3. Comparison of maximum fluid velocities in the nucleus pulposus and the cartilage endplate under compression (comp), flexion (flex), extension (ext), axial rotation (AR) and lateral bending (LB)

component	degree of cartilage endplate degeneration	loading condition
component	degree of cartilage endplate degeneration	comp	flex	ext	AR	LB
nucleus pulposus	calcified	-29.1%	9.5%	-8.6%	0.7%	-1.3%
nucleus pulposus	sclerotic	-19.4%	46.7%	2.6%	15.0%	14.6%
cartilage endplate	calcified	-32.3%	-19.5%	-70.0%	-60.9%	-67.8%
cartilage endplate	sclerotic	-89.3%	-89.5%	-96.4%	-94.5%	-95.4%

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表 4 髓核及软骨终板在压缩、前屈、后伸、轴向旋转及侧弯载荷下的最大主应力比较

Table 4. Comparison of maximum principal stresses in the nucleus pulposus and the cartilage endplate under compression (comp), flexion (flex), extension (ext), axial rotation (AR) and lateral bending (LB)

component	degree of cartilage endplate degeneration	loading condition
component	degree of cartilage endplate degeneration	comp	flex	ext	AR	LB
nucleus pulposus	calcified	77.8%	70.6%	12.5%	69.2%	31.3%
nucleus pulposus	sclerotic	122.2%	94.1%	43.8%	100.0%	56.3%
cartilage endplate	calcified	330.0%	390.6%	571.4%	325.0%	492.3%
cartilage endplate	sclerotic	335.0%	384.4%	595.4%	320.8%	480.8%

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