张力调控影响创口重塑的数值模拟研究

蔡威; 周子星; 张作启; 黄国友

doi:10.21656/1000-0887.450089

张力调控影响创口重塑的数值模拟研究

doi: 10.21656/1000-0887.450089

武汉大学土木建筑工程学院工程力学系，武汉 430072

(我刊青年编委黄国友来稿)

基金项目:

国家自然科学基金 12272278

湖北省自然科学基金 2023AFB586

中央高校基本科研业务费 2042023kf0167

详细信息

作者简介:
蔡威(2003—)，男(E-mail: wekonh20@gmail.com)

周子星(2000—)，男，硕士生(E-mail: 2018302100256@whu.edu.cn)

张作启(1982—)，男，教授，博士，博士生导师(E-mail: Zhang_Zuoqi@whu.edu.cn)

通讯作者:
黄国友(1984—)，男，副教授，博士，博士生导师(通讯作者. E-mail: gyhuang@whu.edu.cn)

中图分类号: O34;Q66
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- 被引次数: 0
出版历程
- 收稿日期: 2024-04-08
- 修回日期: 2024-05-09
- 刊出日期: 2024-06-01

Numerical Simulation Study of Wound Remodeling

Department of Engineering Mechanics, School of Civil Engineering, Wuhan University, Wuhan 430072, P.R.China

(Contributed by HUANG Guoyou, M.AMM Youth Editorial Board)

摘要

摘要:
组织重塑普遍存在于人体的组织和器官，与形态发生、伤口愈合、纤维化发展以及癌症的扩散与转移等密切相关. 力学微环境在组织重塑过程中发挥重要作用，但是，目前张力调控影响创口重塑的规律仍不清. 该文建立了细胞主动收缩引起组织重塑的动态数理模型，并通过有限元方法模拟了不同预张力牵张组织中侧边和内部创口重塑的过程；进一步，基于该模型研究了张力调控对创口重塑的影响. 结果表明，张力调控显著影响创口重塑过程，通过适当的减张作用可以有效降低创口重塑过程中的应力水平和创口大小. 该研究有助于加深人们对于组织重塑过程中力学作用的理解，为从力学角度干预创口重塑过程提供了有用参考.
- 组织重塑 /
- 伤口愈合 /
- 有限元方法 /
- 力学调控
Abstract:
The tissue remodeling is widespread in human tissues and organs, closely associated with morphogenesis, wound healing, fibrosis development, as well as cancer spread and metastasis. The mechanical microenvironment plays a crucial role in the tissue remodeling, yet the impact of tension regulation on wound remodeling remains unclear. A dynamic mathematical model for tissue remodeling induced by active cell contraction was established. The processes of lateral and inner wound remodeling in tissues with different pretensions were simulated with the finite element method. Additionally, the effects of tension regulation on wound remodeling were studied based on the model. The results show that, the tension regulation significantly influences the wound remodeling process, an appropriate tension reduction would effectively decrease the stress magnitude and the wound size. This study contributes to a deeper understanding of the mechanical effects in tissue remodeling and provides references for potential interventions in wound healing.
- tissue remodeling /
- wound healing /
- finite element method /
- mechanical regulation
edited-by

edited-by
注释:

1) (我刊青年编委黄国友来稿)

HTML全文

图 1 牵张组织在细胞收缩作用下的形态演化

注为了解释图中的颜色，读者可以参考本文的电子网页版本，后同.

Figure 1. Morphological evolution of constrained tissue under cell contraction

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图 2 侧边创口在组织重塑过程中的扩展

Figure 2. Lateral wound expansion during tissue remodeling

下载: 全尺寸图片幻灯片

图 3 细胞收缩力对侧边创口演化的影响

Figure 3. The effects of the cell contractility on the evolution of the lateral wound

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图 4 内部创口在组织重塑过程中的扩展

Figure 4. The inner wound expansion during tissue remodeling

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图 5 细胞收缩力对内部创口演化的影响

Figure 5. The effects of the cell contractility on the evolution of the inner wound

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图 6 张力调控下侧边创口的演化

Figure 6. Evolution of the lateral wound under tension regulation

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图 7 张力调控对侧边创口演化的影响

Figure 7. The effects of tension regulation on the evolution of the lateral wound

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图 8 张力调控下内部创口的演化

Figure 8. Evolution of the inner wound under tension regulation

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图 9 张力调控对内部创口演化的影响

Figure 9. The effects of tension regulation on the evolution of the inner wound

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表 1 数值模拟参数

Table 1. simulation parameters

parameter	symbol	value
Mooney-Rivlin parameter 1	C₀₁/Pa	2 000
Mooney-Rivlin parameter 2	C₁₀/Pa	-500
initial bulk modulus	κ/Pa	400
density	ρ/(kg/m³)	1 000
maximum cell contractility	η₀/Pa	300~3 000
dimensionless function parameter	ζ	0.5
boundary displacement	u₀/μm	20~200
initial length of wound	l_w/mm	0.14

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