隐形的曲率：形状如何塑造生命

余坤诺; 徐钊; 卢梦楠; 程波; 徐峰

doi:10.21656/1000-0887.450316

隐形的曲率：形状如何塑造生命

doi: 10.21656/1000-0887.450316

余坤诺^{1, 2,},
徐钊^{1, 2},
卢梦楠^{1, 2},
程波^{1, 2},
徐峰^{1, 2, ,}

1.
西安交通大学生命科学与技术学院生物医学信息工程教育部重点实验室，西安 710049
2.
西安交通大学仿生工程与生物力学研究所(BEBC)，西安 710049

基金项目:

国家自然科学基金 12225208

国家自然科学基金 12432015

国家自然科学基金 12002262

详细信息

作者简介:
余坤诺(2005—)，女(E-mail: yu-kunnuo1125@foxmail.com)

通讯作者:
徐峰(1980—)，男，教授，博士，博士生导师(通讯作者. E-mail: fengxu@mail.xjtu.edu.cn)

中图分类号: O39
计量
- 文章访问数: 9
- HTML全文浏览量: 7
- PDF下载量: 0
- 被引次数: 0
出版历程
- 收稿日期: 2024-11-20
- 修回日期: 2025-01-25
- 网络出版日期: 2025-07-30
- 刊出日期: 2025-07-01

The Invisible Curvature: How Shapes Shape Lives

YU Kunnuo^{1, 2
,},
XU Zhao^{1, 2},
LU Mengnan^{1, 2},
CHENG Bo^{1, 2},
XU Feng^{1, 2
, ,}

1.
Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P.R.China
2.
Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, P.R.China

摘要

摘要: 曲率是描述物体弯曲程度的基本几何特性，在生物学和生物物理过程中起着至关重要的作用.该文探讨了曲率在自然系统中的广泛存在及其对植物、动物和微生物结构与行为的影响.在人体中，曲率表现于多个尺度，从微观的细胞结构到宏观的器官形态，塑造了细胞功能、稳态以及整体生物力学效率.曲率对细胞行为有显著影响，尤其是在黏附、迁移和细胞间通信等过程中，为组织工程等领域提供了重要见解.在病理学上，曲率的改变与多种疾病相关，包括癌症和神经退行性疾病，影响疾病的进展并提供潜在的治疗靶点.此外，曲率在生物医学领域具有广泛应用，如生物成像、组织工程和靶向药物传递.深入理解曲率在生物系统中的作用，不仅可加深对生命过程的理解，也为医学创新和治疗策略的开发开辟了新的途径.
- 曲率 /
- 细胞行为 /
- 病理 /
- 生物医学应用
Abstract: Curvature, a fundamental geometric property that describes the bending of objects, plays a crucial role in biological and biophysical processes. The ubiquitous presence of curvatures in natural systems and its influence on the structures and behaviors of plants, animals, and microorganisms were investigated. In the human body, curvatures are evident at multiple scales, from microscopic cellular structures to the macroscopic organic morphologies, shaping cellular functions, mechanical homeostasis, and overall biomechanical efficiency. Curvatures significantly affect cell behaviors, particularly in processes like adhesion, migration, and intercellular communication, offering insights with implications for tissue engineering. Pathologically, alterations in curvature are associated with a range of diseases including cancers and neurodegenerative disorders, influencing disease progression and providing potential therapeutic targets. Additionally, curvature has diverse biomedical applications, such as in bioimaging, tissue engineering, and targeted drug delivery. A deeper understanding of curvature's role in biological systems not only enhances our comprehension of fundamental life processes but also opens new avenues for medical innovation and therapeutic development.
- curvature /
- cell behavior /
- pathology /
- biomedical application

HTML全文

图 1 曲率的定义

Figure 1. The definition of curvatures

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图 2 自然界中的曲率

注为了解释图中的颜色，读者可以参考本文的电子网页版本，后同.

Figure 2. Curvatures in nature

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图 3 人体中的曲率

Figure 3. Curvatures in the human body

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图 4 曲率对细胞行为的影响

Figure 4. The effects of curvatures on cell behaviors

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