Numerical Simulation Study of Wound Remodeling

CAI Wei; ZHOU Zixing; ZHANG Zuoqi; HUANG Guoyou

doi:10.21656/1000-0887.450089

Volume 45 Issue 6

Jun. 2024

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CAI Wei, ZHOU Zixing, ZHANG Zuoqi, HUANG Guoyou. Numerical Simulation Study of Wound Remodeling[J]. Applied Mathematics and Mechanics, 2024, 45(6): 753-762. doi: 10.21656/1000-0887.450089

Citation:

CAI Wei, ZHOU Zixing, ZHANG Zuoqi, HUANG Guoyou. Numerical Simulation Study of Wound Remodeling[J]. Applied Mathematics and Mechanics, 2024, 45(6): 753-762. doi: 10.21656/1000-0887.450089

Citation:

CAI Wei, ZHOU Zixing, ZHANG Zuoqi, HUANG Guoyou. Numerical Simulation Study of Wound Remodeling[J]. Applied Mathematics and Mechanics, 2024, 45(6): 753-762. doi: 10.21656/1000-0887.450089

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Numerical Simulation Study of Wound Remodeling

doi: 10.21656/1000-0887.450089

Department of Engineering Mechanics, School of Civil Engineering, Wuhan University, Wuhan 430072, P.R.China

Received Date: 2024-04-08
Rev Recd Date: 2024-05-09
Publish Date: 2024-06-01

Abstract

Abstract

The tissue remodeling is widespread in human tissues and organs, closely associated with morphogenesis, wound healing, fibrosis development, as well as cancer spread and metastasis. The mechanical microenvironment plays a crucial role in the tissue remodeling, yet the impact of tension regulation on wound remodeling remains unclear. A dynamic mathematical model for tissue remodeling induced by active cell contraction was established. The processes of lateral and inner wound remodeling in tissues with different pretensions were simulated with the finite element method. Additionally, the effects of tension regulation on wound remodeling were studied based on the model. The results show that, the tension regulation significantly influences the wound remodeling process, an appropriate tension reduction would effectively decrease the stress magnitude and the wound size. This study contributes to a deeper understanding of the mechanical effects in tissue remodeling and provides references for potential interventions in wound healing.
- tissue remodeling,
- wound healing,
- finite element method,
- mechanical regulation

(Contributed by HUANG Guoyou, M.AMM Youth Editorial Board)

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References(27)

References

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