Method on Estimation of Drug's Penetrated Parameters

LIU Yu-hong; ZENG Yan-jun; XU Jing-feng; ZHANG Mei

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Article Navigation > Applied Mathematics and Mechanics > 2004 > 25(4): 400-404

LIU Yu-hong, ZENG Yan-jun, XU Jing-feng, ZHANG Mei. Method on Estimation of Drug's Penetrated Parameters[J]. Applied Mathematics and Mechanics, 2004, 25(4): 400-404.

Citation:

LIU Yu-hong, ZENG Yan-jun, XU Jing-feng, ZHANG Mei. Method on Estimation of Drug's Penetrated Parameters[J]. Applied Mathematics and Mechanics, 2004, 25(4): 400-404.

Citation:

LIU Yu-hong, ZENG Yan-jun, XU Jing-feng, ZHANG Mei. Method on Estimation of Drug's Penetrated Parameters[J]. Applied Mathematics and Mechanics, 2004, 25(4): 400-404.

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Method on Estimation of Drug's Penetrated Parameters

1.
Biomechanical and Medical Information Institute, Beijing Polytechnic University, Beijing 100022, P. R. China;

Received Date: 2001-11-27
Rev Recd Date: 2003-12-02
Publish Date: 2004-04-15

Abstract

Abstract

Transdermal drug delivery system(TDDS) is a new method for drug delivery.The analysis of plenty of experiments in vitro can lead to a suitable mathematical model for the description of the process of the drug's penetration through the skin,together with the important parameters that are related to the characters of the drugs.After the research work of the experiments data,a suitable nonlinear regression model was selected.Using this model,the most important parameter-penetrated coefficient of 20 drugs was computed.In the result one can find,this work supports the theory that the skin can be regarded as singular membrane.
- nonlinear regression model,
- penetration coefficient,
- transdermal drug delivery system(TDDS)

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References(10)

References

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