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张力调控影响创口重塑的数值模拟研究

蔡威 周子星 张作启 黄国友

蔡威, 周子星, 张作启, 黄国友. 张力调控影响创口重塑的数值模拟研究[J]. 应用数学和力学, 2024, 45(6): 753-762. doi: 10.21656/1000-0887.450089
引用本文: 蔡威, 周子星, 张作启, 黄国友. 张力调控影响创口重塑的数值模拟研究[J]. 应用数学和力学, 2024, 45(6): 753-762. doi: 10.21656/1000-0887.450089
CAI Wei, ZHOU Zixing, ZHANG Zuoqi, HUANG Guoyou. Numerical Simulation Study of Wound Remodeling[J]. Applied Mathematics and Mechanics, 2024, 45(6): 753-762. doi: 10.21656/1000-0887.450089
Citation: CAI Wei, ZHOU Zixing, ZHANG Zuoqi, HUANG Guoyou. Numerical Simulation Study of Wound Remodeling[J]. Applied Mathematics and Mechanics, 2024, 45(6): 753-762. doi: 10.21656/1000-0887.450089

张力调控影响创口重塑的数值模拟研究

doi: 10.21656/1000-0887.450089
基金项目: 

国家自然科学基金 12272278

湖北省自然科学基金 2023AFB586

中央高校基本科研业务费 2042023kf0167

详细信息
    作者简介:

    蔡威(2003—),男(E-mail: wekonh20@gmail.com)

    周子星(2000—),男,硕士生(E-mail: 2018302100256@whu.edu.cn)

    张作启(1982—),男,教授,博士,博士生导师(E-mail: Zhang_Zuoqi@whu.edu.cn)

    通讯作者:

    黄国友(1984—),男,副教授,博士,博士生导师(通讯作者. E-mail: gyhuang@whu.edu.cn)

  • (我刊青年编委黄国友来稿)
  • 中图分类号: O34;Q66

Numerical Simulation Study of Wound Remodeling

  • (Contributed by HUANG Guoyou, M.AMM Youth Editorial Board)
  • 摘要:

    组织重塑普遍存在于人体的组织和器官,与形态发生、伤口愈合、纤维化发展以及癌症的扩散与转移等密切相关. 力学微环境在组织重塑过程中发挥重要作用,但是,目前张力调控影响创口重塑的规律仍不清. 该文建立了细胞主动收缩引起组织重塑的动态数理模型,并通过有限元方法模拟了不同预张力牵张组织中侧边和内部创口重塑的过程;进一步,基于该模型研究了张力调控对创口重塑的影响. 结果表明,张力调控显著影响创口重塑过程,通过适当的减张作用可以有效降低创口重塑过程中的应力水平和创口大小. 该研究有助于加深人们对于组织重塑过程中力学作用的理解,为从力学角度干预创口重塑过程提供了有用参考.

    (Contributed by HUANG Guoyou, M.AMM Youth Editorial Board)
    1)  (我刊青年编委黄国友来稿)
  • 图  1  牵张组织在细胞收缩作用下的形态演化

      为了解释图中的颜色,读者可以参考本文的电子网页版本,后同.

    Figure  1.  Morphological evolution of constrained tissue under cell contraction

    图  2  侧边创口在组织重塑过程中的扩展

    Figure  2.  Lateral wound expansion during tissue remodeling

    图  3  细胞收缩力对侧边创口演化的影响

    Figure  3.  The effects of the cell contractility on the evolution of the lateral wound

    图  4  内部创口在组织重塑过程中的扩展

    Figure  4.  The inner wound expansion during tissue remodeling

    图  5  细胞收缩力对内部创口演化的影响

    Figure  5.  The effects of the cell contractility on the evolution of the inner wound

    图  6  张力调控下侧边创口的演化

    Figure  6.  Evolution of the lateral wound under tension regulation

    图  7  张力调控对侧边创口演化的影响

    Figure  7.  The effects of tension regulation on the evolution of the lateral wound

    图  8  张力调控下内部创口的演化

    Figure  8.  Evolution of the inner wound under tension regulation

    图  9  张力调控对内部创口演化的影响

    Figure  9.  The effects of tension regulation on the evolution of the inner wound

    表  1  数值模拟参数

    Table  1.   simulation parameters

    parameter symbol value
    Mooney-Rivlin parameter 1 C01/Pa 2 000
    Mooney-Rivlin parameter 2 C10/Pa -500
    initial bulk modulus κ/Pa 400
    density ρ/(kg/m3) 1 000
    maximum cell contractility η0/Pa 300~3 000
    dimensionless function parameter ζ 0.5
    boundary displacement u0/μm 20~200
    initial length of wound lw/mm 0.14
    下载: 导出CSV
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    WEN Guangquan, JI Xiaogang, DUAN Yushun, et al. A prediction model for skin wound suture forces with uncertain material parameters[J]. Applied Mathematics and Mechanics, 2023, 44(4): 441-449. (in Chinese) doi: 10.21656/1000-0887.430067?viewType=HTML
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出版历程
  • 收稿日期:  2024-04-08
  • 修回日期:  2024-05-09
  • 刊出日期:  2024-06-01

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