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抗血管生成药物Endostantin作用下实体肿瘤血管生成的数值模拟:考虑基质力学环境及血管生成抑素的影响

蔡彦 吴洁 古娜 张洪一 曹金凤 许世雄 龙泉 柯林斯

蔡彦, 吴洁, 古娜, 张洪一, 曹金凤, 许世雄, 龙泉, 柯林斯. 抗血管生成药物Endostantin作用下实体肿瘤血管生成的数值模拟:考虑基质力学环境及血管生成抑素的影响[J]. 应用数学和力学, 2009, 30(10): 1165-1172. doi: 10.3879/j.issn.1000-0887.2009.10.004
引用本文: 蔡彦, 吴洁, 古娜, 张洪一, 曹金凤, 许世雄, 龙泉, 柯林斯. 抗血管生成药物Endostantin作用下实体肿瘤血管生成的数值模拟:考虑基质力学环境及血管生成抑素的影响[J]. 应用数学和力学, 2009, 30(10): 1165-1172. doi: 10.3879/j.issn.1000-0887.2009.10.004
CAI Yan, WU Jie, Kalkabay Gulnar, ZHANG Hong-yi, CAO Jin-feng, XU Shi-xiong, Quan Long, M. W. Collins. Numerical Simulation of Solid Tumor Angiogenesis With Endostatin Treatment: a Combined Analysis of Anti-Angiogenic Factor Inhibiting Effect and Extra-Cellular Matrix Micro Mechanical Environment[J]. Applied Mathematics and Mechanics, 2009, 30(10): 1165-1172. doi: 10.3879/j.issn.1000-0887.2009.10.004
Citation: CAI Yan, WU Jie, Kalkabay Gulnar, ZHANG Hong-yi, CAO Jin-feng, XU Shi-xiong, Quan Long, M. W. Collins. Numerical Simulation of Solid Tumor Angiogenesis With Endostatin Treatment: a Combined Analysis of Anti-Angiogenic Factor Inhibiting Effect and Extra-Cellular Matrix Micro Mechanical Environment[J]. Applied Mathematics and Mechanics, 2009, 30(10): 1165-1172. doi: 10.3879/j.issn.1000-0887.2009.10.004

抗血管生成药物Endostantin作用下实体肿瘤血管生成的数值模拟:考虑基质力学环境及血管生成抑素的影响

doi: 10.3879/j.issn.1000-0887.2009.10.004
基金项目: 国家自然科学基金资助项目(10372026;10772751);上海市重点学科基金资助项目(B112)
详细信息
    作者简介:

    蔡彦(1984- ),女,安徽安庆人,博士;许世雄(联系人.Tel:+86-21-65643813;E-mail:xusx@homtail.com).

  • 中图分类号: R318.01;TB115 A

Numerical Simulation of Solid Tumor Angiogenesis With Endostatin Treatment: a Combined Analysis of Anti-Angiogenic Factor Inhibiting Effect and Extra-Cellular Matrix Micro Mechanical Environment

  • 摘要: 为研究抗血管生成药物Endostatin作用下,肿瘤血管生成过程中基质力学环境及血管生成抑素的影响,考虑内皮细胞(EC)和细胞外基质(ECM)两相,耦合抗血管生成药物Endostatin和血管生成抑素Angiostatin的抑制效应,建立肿瘤内外血管生成的二维数值模型.抗血管生成因子Angiostatin和药物Endostatin耦合作用时,可明显降低肿瘤组织内的微血管密度,对肿瘤快速生长起到一定的抑制作用.所给出的模型,可以较好模拟基质力学环境影响下,肿瘤抗血管生成因子对内皮细胞迁移和增殖的抑制作用
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出版历程
  • 收稿日期:  2009-01-06
  • 修回日期:  2009-08-19
  • 刊出日期:  2009-10-15

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